Glossary

Alzheimer’s
A progressive brain condition marked by the buildup of abnormal proteins and gradual loss of memory, thinking skills, and independence over time. BATWATCH™ approaches Alzheimer’s not as an inevitable fate, but as a process of biological drift that can be tracked early through blood-based biomarkers, often years before symptoms start. By monitoring and managing key drivers like Beta-Amyloid, Tau, inflammation, and metabolic changes, BATWATCH™ aims to give patients a window of action to protect long-term brain health and reduce lifetime risk.

APOE4 Variant (BATWATCH™ Risk Factor):
A key genetic marker tracked in the BATWATCH™ Protocol for identifying individuals with higher potential for biological drift. The presence of the APOE4 Variant increases your BAT LEVEL INDEX™ and signals the need for earlier BAT TESTING™ and proactive brain health monitoring. While APOE4 does not guarantee a future diagnosis, it’s a core factor in BATWATCH™ risk stratification and personalized guidance.

Autophagy (BATWATCH™ Cleanup Pathway):
The natural cellular process BATWATCH™ leverages to support brain health. Autophagy acts as your body’s internal cleanup crew, removing buildup and supporting balanced BAT LEVELS™. The BAT Pill Protocol is designed to trigger autophagy, helping users clear biological drift and optimize their BAT SCORE™ within the BATWATCH™ ecosystem.

BAT CHECK™:
The BAT CHECK™ is BATWATCH™’s flagship annual screening, your first step to knowing your BAT SCORE™. It’s a simple, blood-based test designed to catch early signs of biological drift, even before symptoms show up. BAT CHECK™ is your brain’s “check engine light”, if there’s a shift, you’ll know, and BATWATCH™ will guide you on what to do next.

BAT Drift Engine:
The proprietary decision system within BATWATCH™ that combines BAT LEVELS™, risk profiles, and other biomarkers to calculate personalized risk and guide next steps. It powers recommendations for testing, intervention, and prevention.

BAT Level Awareness Month:
BAT Level Awareness Month is a national campaign created by BATWATCH™ to spotlight the importance of tracking your BAT LEVELS™ early, well before symptoms or concerns arise. Each year, BAT Level Awareness Month brings education, free BAT CHECK™ events, and brain health challenges to the public, making it easier for everyone to get their BAT SCORE™, join the movement, and take action for lifelong prevention.

BAT LEVEL INDEX™:
The BAT LEVEL INDEX™ is BATWATCH™’s proprietary scoring system that combines your BAT LEVELS™, risk factors, and clinical data into one clear number, your BAT SCORE™. This index is your brain’s personal dashboard, making it easy to see where you stand, track progress, and guide next steps. The BAT LEVEL INDEX™ powers all decisions within the BATWATCH™ Protocol and is the gold standard for personalized brain health monitoring.

BAT LEVELS™:
BAT LEVELS™ are the core biomarkers measured by BATWATCH™ to track your brain’s health over time. They represent the balance, or drift, of key proteins linked to long-term brain risk. Monitoring your BAT LEVELS™ with BAT TESTING™ and the BAT LEVEL INDEX™ helps you see changes early, stay ahead of biological accumulation, and take targeted steps to protect your future brain health.

BAT PILL™:
The BAT PILL™ is BATWATCH™’s targeted intervention designed to activate your body’s natural cleanup system (autophagy) and help clear biological accumulation. Used within the BAT PILL™ Protocol, it supports lower BAT LEVELS™, better brain resilience, and ongoing prevention, all guided by your BAT SCORE™ and the BATWATCH™ Protocol.

BAT PILL™ Protocol:
The BAT PILL™ Protocol is BATWATCH™’s structured, step-by-step approach to using the BAT Pill for maximum impact. It covers everything from timing and dosing to monitoring and follow-up, ensuring the intervention is safe, effective, and personalized to your BAT SCORE™. The BAT PILL™ Protocol is the go-to method for anyone ready to take action on biological drift and protect long-term brain health within the BATWATCH™ ecosystem.

BAT SCORE™:
Your BAT SCORE™ is the single, easy-to-understand number generated by the BAT LEVEL INDEX™. It reflects your current biological status, showing how much drift is happening and where you stand on your brain health journey. Tracking your BAT SCORE™ over time with BATWATCH™ makes it simple to spot changes, measure improvement, and know when to take action for prevention.

BAT TEST™:
The BAT TEST™ is the core blood-based biomarker test in the BATWATCH™ Protocol, used to measure your BAT LEVELS™ and generate your BAT SCORE™. Designed for early detection, the BAT TEST™ makes it easy to catch biological drift long before symptoms appear. Every BAT TEST™ you take builds your personal brain health timeline and powers smarter decisions across the BATWATCH™ ecosystem.

BAT TESTING™:
BAT TESTING™ is the process of measuring your BAT LEVELS™ using BATWATCH™-approved blood-based tests. It’s the foundation of the BATWATCH™ Protocol, allowing you and your clinician to detect biological drift early, track changes over time, and make informed decisions using your BAT SCORE™ and BAT LEVEL INDEX™. Regular BAT TESTING™ keeps your brain health in focus, year after year.

BATOPHAGY™ (BATWATCH™-Driven Brain Cleanup):
A BATWATCH™-specific term for activating autophagy to clear brain-based biological accumulation. BATOPHAGY™ describes the targeted process, via the BAT PILL™ Protocol, where we support the removal of excess buildup to stabilize BAT LEVELS™ and drive down your BAT SCORE™. It’s the science-backed mechanism behind BATWATCH™’s preventive approach.

BATWATCH™:
BATWATCH™ is a next-generation brain health platform and ecosystem, built to monitor, track, and help you manage biological drift before symptoms ever appear. BATWATCH™ unites advanced biomarker testing, AI-powered analytics, and a global network of clinicians, all using BATWATCH™-branded tools like the BAT LEVEL INDEX™ and BAT CHECK™, to make prevention simple, personal, and actionable. Whether you’re checking your BAT SCORE™ for the first time or following a long-term BATWATCH™ Protocol, you’re part of a movement redefining how brain health is measured and protected.

BATWATCH™ AI
The proprietary artificial intelligence engine that analyzes BAT LEVELS™, tracks drift, and generates personalized recommendations throughout the BATWATCH™ ecosystem. BATWATCH™ AI helps transform raw data into actionable insights for users and clinicians alike.

BATWATCH™ Average Risk Profile:
A classification used in the BAT LEVEL INDEX™ for individuals typically 40+ with no family history of Alzheimer’s, stable lifestyle habits, and no major exposure to risk factors like smoking, heavy drinking, or chronic stress. Falling into the BATWATCH™ Average Risk Profile means your BAT SCORE™ is in the moderate range, still vulnerable to drift, but positioned for the best results with early BAT TESTING™ and ongoing monitoring.

BATWATCH™ Data Lake
BATWATCH™ secure, centralized repository for all longitudinal biomarker, outcome, and protocol data. The Data Lake powers AI-driven insights, ongoing research, and personalized prevention strategies.

BATWATCH™ Elevated Risk Profile:
A classification in the BAT LEVEL INDEX™ for individuals typically age 30+ who are already stacking up biological risk factors, family history of Alzheimer’s, smoking, drinking, vaping, poor sleep, chronic stress, or other contributors to brain drift. If you fall into the BATWATCH™ Elevated Risk Profile, your BAT SCORE™ is above average, meaning drift is likely underway. BAT TESTING™and early intervention are especially important in this group, since these risk factors can accelerate biological accumulation and make long-term prevention more urgent.

BATWATCH™ Network
The collective of clinicians, researchers, and partners leveraging BATWATCH™ protocols and technology to advance preventive brain health at scale. The BATWATCH™ Network enables nationwide and global access, sharing data, insights, and best practices for early intervention.

BATWATCH™ Protocol:
The BATWATCH™ Protocol is a comprehensive, step-by-step framework for monitoring, managing, and optimizing brain health using the BAT LEVEL INDEX™, BAT TESTING™, and targeted interventions like the BAT PILL™ Protocol. It integrates early detection, risk stratification, and personalized action plans, all using BATWATCH™-branded tools and guidance, to help you track, reduce, and stay ahead of biological drift. The BATWATCH™ Protocol adapts as new science and technologies emerge, setting the standard for proactive, evidence-based prevention.

BATWATCH™ Registry:
The BATWATCH™ Registry is a secure, longitudinal database that tracks BAT LEVELS™, BAT SCORE™, and related biomarker data across thousands of users over time. It’s the world’s first and largest resource dedicated exclusively to monitoring brain health trends, supporting research, and powering better clinical decision-making within the BATWATCH™ ecosystem. By joining the BATWATCH™ Registry, you contribute to advancing prevention science, benchmarking your BAT LEVEL INDEX™ against national trends, and enabling smarter, personalized recommendations as new discoveries emerge.

Beta-Amyloid Protein:
Beta-Amyloid Protein is one of the key biological markers tracked by BATWATCH™. It’s a protein that, when it starts to build up, can signal the early stages of biological drift in the brain. Monitoring Beta-Amyloid levels helps BATWATCH™ users catch changes long before symptoms and take steps to maintain healthy brain function.

Biological Accumulation Threshold:
The Biological Accumulation Threshold is the tipping point where your body’s cleanup systems can no longer keep up with buildup, and biological drift starts to accelerate. BAT LEVELS™ rising above this threshold signal it’s time to act, using BATWATCH™ tools like the BAT TEST™ and BAT PILL™ Protocol, to clear the excess and restore balance before bigger problems develop.

Biological Drift:
Biological Drift is BATWATCH™ term for the slow, often silent accumulation of changes in your body that can push your brain off track over time. It’s the subtle shift, measurable in your BAT LEVELS™, that happens years before symptoms ever show up. BATWATCH™ is built to catch and correct biological drift early, using tools like the BAT TEST™ and BAT LEVEL INDEX™ to help you stay ahead of risk.

Biological Warning Light:
The Biological Warning Light is BATWATCH™’s way of describing those early signals, like changes in your BAT LEVELS™, that alert you when your brain’s systems are starting to drift. Just like your car’s “check engine” light, the Biological Warning Light means it’s time to check your BAT SCORE™, investigate what’s driving the change, and take action for prevention before real damage occurs.

Biomarker-Driven Prevention:
Biomarker-Driven Prevention is the BATWATCH™ philosophy of using real, measurable markers, like BAT LEVELS™ and the BAT LEVEL INDEX™, to guide early action. Instead of guessing or waiting for symptoms, BATWATCH™ empowers you to use science-backed data to track, predict, and prevent biological drift, giving you a clearer path to lifelong brain health.

Biomarker Timeline / Brain Health Timeline:
The longitudinal record of BAT LEVELS™, interventions, and risk factors captured in the BATWATCH™ ecosystem, helping users and clinicians visualize change, progress, and opportunities for early action.

Blood-based Biomarkers:
Blood-based Biomarkers are the measurable signals in your blood, like those tracked by the BAT TEST™, that reveal early changes in brain biology. BATWATCH™ uses blood-based biomarkers as the foundation for monitoring your BAT LEVELS™, calculating your BAT SCORE™, and guiding prevention long before symptoms or concerns arise.

Brain Health Command Center:
The Brain Health Command Center is BATWATCH™’s all-in-one dashboard that brings together your BAT LEVELS™, BAT SCORE™, testing history, and personalized recommendations. It’s your control hub for tracking trends, receiving alerts, and taking action, making proactive brain health management simple, visual, and easy to navigate from anywhere.

Brain’s Check Engine Light:

Brain’s Check Engine Light is BATWATCH™’s signature analogy for the BAT TEST™ and BAT SCORE™, early warning signals that let you know when your brain is starting to drift off track. Just like your car’s check engine light, it’s not a diagnosis; it’s a prompt to investigate, make adjustments, and stay ahead of bigger problems by taking action now.

Cellular Cleanup System:
A term used in BATWATCH™ to describe the body’s natural processes for clearing out waste, damaged proteins, and cellular debris, primarily through autophagy and related biological pathways. A well-functioning Cellular Cleanup System helps maintain brain health by preventing the buildup of harmful materials like beta-amyloid and tau. When this system slows down or stalls, it can lead to biological drift and rising BAT LEVELS™.

Cholesterol for the Brain:
A simple analogy used in BATWATCH™ to explain how BAT LEVELS™ function as early warning markers for brain health, similar to how cholesterol serves as a warning sign for heart health. Just as you wouldn’t wait for a heart attack to check your cholesterol, you shouldn’t wait for problems to check your BAT LEVELS™. Monitoring these “cholesterol for the brain” markers helps you catch biological drift early, empowering you to take action long before symptoms or decline.

Chronic Inflammation:
A persistent, low-grade immune response in the body that can disrupt brain health over time. In BATWATCH™, chronic inflammation is tracked as one of the key drivers of biological drift, accelerating the buildup of harmful proteins and interfering with the brain’s ability to clear waste. Addressing chronic inflammation is essential for maintaining optimal BAT LEVELS™ and protecting long-term brain function.

Clearance Check:
Clearance Check is the final step in the BATWATCH™ Protocol after an intervention, like the BAT PILL™ Protocol. It’s a follow-up blood test that measures how well your body has cleared biological buildup and whether your BAT LEVELS™ have returned to a safer range. The Clearance Check confirms your progress and helps plan ongoing monitoring to keep drift in check.

Cognitive Reserve:
The concept of building up the brain’s resilience and repair systems through early intervention, tracked in the BATWATCH™ Protocol by BAT LEVELS™, risk factors, and lifestyle changes.

Confirmation Testing:
A follow-up lab process in the BATWATCH™ Protocol that verifies initial BAT TEST™ results. Confirmation Testing involves repeating BAT Level measurements, usually at a different date or lab, to ensure accuracy, rule out false positives, and establish a clear trend before moving forward with intervention or further stratification. This step is essential for building confidence in each patient’s BAT SCORE™ and next steps.

Cortisol Dysregulation / HPA Axis:
A disruption in the body’s stress hormone system, the hypothalamic-pituitary-adrenal (HPA) axis, that leads to abnormal cortisol levels. In the BATWATCH™ framework, cortisol dysregulation is recognized as a hidden driver of biological drift, affecting everything from metabolism and inflammation to sleep and brain repair. Chronic stress and HPA axis imbalances can accelerate changes in BAT LEVELS™ and increase vulnerability to long-term brain health concerns.

Decentralized Care:
The BATWATCH™ model of delivering advanced brain health monitoring, coaching, and intervention remotely, enabling national (and global) access to top-tier prevention, regardless of location.

Digital Biomarker:
Non-invasive, technology-driven data points, like those collected via the BATWATCH™ platform, smart devices, or remote monitoring, that help track biological drift and optimize prevention outside the traditional clinic.

Drift Markers / Drift Indicators:
Short for biological markers tracked by BATWATCH™ that reveal the earliest signs of drift, before symptoms or overt disease. Includes BAT LEVELS™, inflammation, metabolic markers, and more. Drift Markers help users see what’s changing beneath the surface.

Empowered Brain Health:
The BATWATCH™ mission: giving people the tools, data, and community to take charge of their brain health, track drift early, and act long before decline.

Environmental Exposures:
Factors from your surroundings, like air pollution, heavy metals, pesticides, and chemical toxins, that can impact your brain’s long-term health. Chronic or high-level exposure can accelerate biological drift by increasing inflammation, oxidative stress, and the accumulation of unwanted proteins. BATWATCH™ considers environmental exposures in risk assessments and personalized prevention strategies.

Factor Check:
Factor Check is a follow-up blood panel in the BATWATCH™ Protocol, designed to dig deeper into what’s driving your BAT SCORE™. After an initial BAT TEST™ shows drift, the Factor Check looks for other influences, like inflammation, metabolic stress, or hormone imbalance, helping you and your clinician target the right next steps for personalized prevention.

Family History of Alzheimer’s:
A known risk factor tracked in the BAT LEVEL INDEX™ and risk profiles. Having a close family member (parent or sibling) diagnosed with Alzheimer’s increases your biological drift potential, meaning you may need earlier or more frequent BAT TESTS™ and targeted prevention strategies. Family history is just one piece of your overall risk picture and does not guarantee future diagnosis.

Glymphatic System:
The brain’s natural “waste clearance” pathway, a fluid-based network that flushes out toxins, metabolic byproducts, and protein buildup (like beta-amyloid and tau) during deep sleep. In the BATWATCH™ model, optimal glymphatic flow is critical for maintaining healthy BAT LEVELS™, while disruptions in this system are linked to early biological drift and increased risk of long-term brain health issues.

Hormonal Imbalance:
A disruption in the body’s hormone systems, such as thyroid, estrogen, testosterone, insulin, or cortisol, that can impact the brain’s ability to maintain balance, repair, and protect itself. In the BATWATCH™ approach, hormonal imbalances are recognized as drivers of biological drift, influencing BAT LEVELS™ and long-term brain health risk, especially when combined with other metabolic or inflammatory factors.

Impaired Lipid Clearance:
A breakdown in the brain’s ability to transport and remove fats, cholesterol, and related molecules, often involving APOE4 genetics or metabolic dysfunction. In the BATWATCH™ framework, impaired lipid clearance can lead to buildup of harmful proteins, drive biological drift, and elevate BAT LEVELS™ over time, making it a key mechanism to address in prevention strategies.

Insulin Resistance:
A metabolic condition where the body’s cells become less responsive to insulin, leading to higher blood sugar and increased inflammation. Insulin resistance can accelerate biological drift, contribute to the buildup of brain biomarkers tracked in BAT LEVELS™, and increase long-term risk for neurological issues. Monitoring and addressing insulin resistance is a key part of prevention and optimization in the BATWATCH™ Protocol.

Lipid Transport:
The biological process by which fats (lipids) are moved throughout the body, including the brain. Efficient lipid transport is essential for clearing waste products and supporting healthy brain cell membranes. Impaired lipid transport can slow down the removal of harmful proteins, raising BAT LEVELS™ and increasing biological drift. BATWATCH™ tracks these processes as part of its prevention and optimization strategies.

Living database:
A dynamic, continuously updated collection of scientific studies, clinical data, and global research findings that powers BATWATCH™’s protocols. Our living database uses advanced AI and expert review to scan, analyze, and integrate new evidence in real time, ensuring our brain health strategies and BAT SCORE™ recommendations are always grounded in the latest science.

Longitudinal Monitoring:
Continuous tracking of BAT LEVELS™, biomarker trends, and intervention results over time, creating a living health timeline and enabling smarter, adaptive prevention.

Metabolic dysfunction:
A disruption in the body’s ability to process and use energy efficiently, often tied to insulin resistance, poor lipid handling, and chronic inflammation. In the BATWATCH™ Protocol, metabolic dysfunction is tracked as a core driver of biological drift, increasing risk for elevated BAT LEVELS™ and long-term brain health issues. Early detection and targeted intervention can help restore metabolic balance and reduce risk over time.

Metabolism of the Brain:
Refers to how your brain processes energy, nutrients, and waste, key functions tracked in BATWATCH™ risk models. Healthy brain metabolism ensures efficient fuel use, toxin clearance, and signal transmission. Disruptions in brain metabolism, often due to insulin resistance, mitochondrial dysfunction, or chronic inflammation, can accelerate biological drift and influence your BAT LEVELS™.

Mitochondrial Dysfunction:
A decline in the efficiency of your brain’s cellular “power plants”, the mitochondria, that produce energy for every brain cell. In BATWATCH™, mitochondrial dysfunction is tracked as a major factor driving biological drift, reduced energy, and impaired brain resilience. Over time, this can raise BAT LEVELS™ and increase long-term risk.

Mitochondrial Stress:
A state where the brain’s mitochondria are under pressure from factors like toxins, inflammation, or chronic metabolic overload. In the BATWATCH™ Protocol, mitochondrial stress is recognized as a key early signal that your brain’s energy supply is struggling, which can set the stage for increased BAT LEVELS™ and greater vulnerability to drift.

mTOR Signaling:
A central cellular pathway that controls growth, metabolism, and the balance between building up and breaking down cellular components. In BATWATCH™, mTOR signaling is important because its overactivation can block autophagy, the brain’s natural cleanup process, allowing harmful proteins to accumulate. Managing mTOR activity helps restore cellular cleanup, supporting long-term brain health and optimal BAT LEVELS™.

Neuroinflammation:
A chronic, low-grade inflammatory response within the brain and central nervous system, often triggered by injury, infection, metabolic imbalance, or protein buildup. In BATWATCH™, neuroinflammation is seen as a core mechanism behind early biological drift, accelerating the accumulation of damaging proteins and increasing BAT LEVELS™. Addressing neuroinflammation is central to prevention and maintaining long-term brain health.

Oxidative Stress:
A biological state where there’s an imbalance between damaging free radicals (reactive oxygen species) and the body’s ability to neutralize them with antioxidants. In the BATWATCH™ framework, oxidative stress is recognized as a key driver of brain aging and protein buildup, as it damages cells, disrupts normal repair, and accelerates biological drift, contributing to higher BAT LEVELS™ over time.

Personalized Prevention:
The BATWATCH™ approach to using biomarker and risk stratification data to deliver tailored recommendations for each user, moving beyond generic advice to truly individualized brain health plans.

Preclinical Detection:
The process of identifying biological changes and drift years before symptoms or traditional diagnoses. BATWATCH™ is built around preclinical detection, empowering users to take action at the very first sign of risk.

Preventive Prescription:
A BATWATCH™-guided, protocol-driven use of interventions (like the BAT PILL™) to reduce biological drift, even in the absence of symptoms, moving prevention into routine clinical care.

Population Health (BATWATCH™):
The science and strategy of applying BATWATCH™ tools across large groups to track drift, predict risk, and deliver preventive brain health at scale, empowering health systems, employers, and payers.

Real-world evidence (RWE):
Data and insights collected from actual patient experiences, outcomes, and health system records, outside of controlled clinical trials. At BATWATCH™, RWE is used to validate how biomarker-driven prevention, protocols, and interventions perform in real-life settings, tracking trends and results as they happen. This helps improve recommendations, personalize care, and ensure that protocols work not just in theory, but for real people in the real world.

Risk Stratification:
The process of categorizing individuals based on their unique combination of biological markers, lifestyle factors, genetics, and medical history to determine their likelihood of experiencing early brain health drift. In BATWATCH™, risk stratification helps personalize BAT TEST™ schedules, guide next steps, and ensure interventions are matched to each person’s needs, moving beyond “one-size-fits-all” prevention.

Short-Cycle Intervention:
A focused, time-limited protocol designed to quickly address early signs of biological drift before they become long-term problems. In the BATWATCH™ framework, a short-cycle intervention, like the BAT PILL™ Protocol, uses a brief sequence of targeted support to help restore healthy biomarker balance and return users to prevention mode, rather than indefinite medication management.

Sleep Disruption:
Changes in sleep quality, duration, or rhythm that interfere with the brain’s natural repair and cleanup cycles. In the BATWATCH™ system, sleep disruption is recognized as a key driver of biological drift, since healthy sleep is essential for clearing waste, regulating inflammation, and keeping BAT LEVELS™ in check. Chronic sleep disruption can accelerate risk for long-term brain health issues, making it an important focus for prevention and intervention.

Tau Protein / Phosphorylated Tau (pTau):
Tau Protein, including its phosphorylated form (pTau), is a major biomarker measured by BATWATCH™. When Tau or pTau levels start to rise, it signals internal friction and stress within brain cells, often showing up as biological drift long before any symptoms. BATWATCH™ tracks Tau alongside other markers to give you an early warning and guide prevention strategies before problems develop.

Testing Evidence Matrix
BATWATCH™’s proprietary, AI-powered living database that continuously integrates thousands of studies spanning neuroscience, diagnostics, genomics, prevention, and more. The Matrix combines landmark trials, meta-analyses, policy research, and global health data, powering all BATWATCH™ protocol development, testing recommendations, and risk stratification. It ensures every BATWATCH™ decision is grounded in the most current, comprehensive, and evidence-based science.

Testing Function:
Refers to traditional cognitive or neurological tests, like memory assessments, paper-based tasks, or performance-based screenings, that measure how well your brain is currently working. Testing function is about present-day abilities, not underlying biology.

Testing Biology:
Describes biomarker-driven testing used by BATWATCH™, such as blood-based lab panels that reveal what’s happening beneath the surface, tracking early biological drift, accumulation, and risk long before symptoms or changes in function appear. Testing biology shows the root cause, not just the result.

Treatment Evidence Matrix
BATWATCH™’s proprietary, AI-driven living database of clinical evidence, tracking every major intervention, therapy, and prevention strategy in brain health. This Matrix synthesizes global trial results, real-world evidence, and emerging science, guiding BAT PILL™ Protocols, intervention recommendations, and ongoing optimization. Every BATWATCH™ treatment approach is anchored to the most up-to-date, rigorous, and actionable clinical research available.